Chief of Cardiology, Winthrop University Hospital 2003-present
Director of Cardiovascular Quality Management 2005-present
Director of Women’s Cardiovascular Wellness and Prevention Center 2008-present
Director of Cardiac Catheterization Laboratory , 1997-2005
Attending Cardiologist Winthrop University Hosptial 1992-present
University of Pennsylvania, Interventional and General Cardiology Fellowship 1988-92
Columbia University, Presbyterian Hospital- Internal Medicine Residency 1985-88
Northwestern University Medical School 1981-85
Description of Research Interests/Activities
Preventive Cardiology and effects of lifestyle intervention on Endothelial Dysfunction
Antiplatelet Strategies in Acute Coronary Syndromes and following Coronary Interventions
Risk Assessment in Acute Coronary Syndromes in Women
Optimizing Reperfusion Strategies in Acute Myocardial Infarction
Principal Investigator/Sub-Investigator Sponsored Clinical Trials
1. GUSTO IV (AMI)
2. PRESTO (TRANILAST FOR RESTENOSIS)
3. OAT (OPEN ARTERY TRIAL)
4. POSTIT (INTRAVASCULAR ULTRASOUND IN STENT DEPLOYMENT)
5. TIMI 18/ Tactics Trial
6. ADORE Trial
9. ReoPro Readministration Registry (R3 study) (PI)
11. SHOCK Trial – Sub-Investigator
12. TIMI 15B – Sub-Investigator
13. VEGF Trial – Sub-Investigator
14. In-TIME II Trial – Sub-Investigator
15. CAPTIVE Trial
16. FINESSE Trial
17. ACUITY Study
18. APEX AMI
19. MERLIN TIMI 36
20. TRITON TIMI 38
24. OMEGA III
26. XIENCE Registry
28. PROTECT II
31. ST SEGMENT DETECTION STUDY
Principal Investigator/Sub-Investigator-Initiated Research Projects:
1. Walking Employees Heart-Healthy Lifestyle Lessons: Nutrition and Exercise Strategies for Success (WELLNESS) Study.
2. Peripheral Endothelial Properties – The Role A Hospital-Wide Weight Loss Initiative Has on Function (PEP-RALI Study)
Areas of Experience
Research Team Members
Advanced Practice Nurse Coordinator: Wendy Drewes, BSN, RN:
At Winthrop since 2006, Ms. Drewes joined the team in the Division of Cardiology initially in the position of Cardiology Clinical Coordinator for both research and heart failure services. Clinical research duties include but are not limited to working collaboratively with Cardiology Principal Investigators and industry sponsors in coordinating all components of cardiology clinical research including IRB submission, forms development and subject follow-up. Ms. Drewes is actively involved with a variety of cardiovascular clinical research projects including several large, muticenter trials that are addressing the relationship between diabetes and CVD inflammation. In addition to coordination of research and heart failure services, Ms. Drewes has assumed the role of coordinating advanced clinical and managerial nursing activities related to both primary and secondary prevention programs, including the Women’s Cardiovascular Wellness & Prevention Center. The cardiovascular services involved include Education (Patient, Professional), Clinical Programs and Research.
Advanced Practice Nurse Coordinator: Dipti Patel, RN, MPH, MS, CDN:
At Winthrop since 2004, Ms. Patel joined the Division of Cardiology after working several years as a telemetry nurse. She is responsible for all regulatory documentation associated with the in-patient clinical trials including IRB communications, protocol and consent approvals, addendums, amendments, adverse events and annual study updates. Ms. Patel is actively involved with a variety of in-patient cardiovascular clinical research projects including several, large multicenter trials associated with the latest, most advanced interventional techniques used for the treatment of coronary artery disease. In addition to coordinating in-patient clinical trials, she is actively involved with all aspects of the hospital’s heart failures service.
Clinical Practice and Interests
Acute Coronary Sydromes
Antithrombin and Antiplatelet Therapies
Preventive Cardiology and Intergrative Cardiology
1. Marzo KP, Frey M, Wilson JR, Liang BT, Manning DR, Molinoff P: The B-adrenergic-G-protein-adenylyl cyclase complex in experimental canine congestive heart failure produced by rapid ventricular pacing. Circulation Research 1991-69, 1546-1556
2. Marzo KP, Wilson JR, Mancini DM: Excessive ventilatory response to exercise persists following cardiac transplantation. Am J Card 1992: 62, 547-553
3. Marzo KP, Herrmann HJ, Mancini DM: The acute and chronic effects of percutaneous balloon mitral valvuloplasty on exercise capacity, ventilation and skeletal muscle oxygenation. J Am Coll Cardiol 1993; 21: 856-65
4. Mellow E, Redie E, Marzo KP, Wilson JR: Effect of chronic left ventricular failure on endogenous opiates. Journal of Applied Physiology, 73 (6): 2675-80, 1992 Dec.
5. Kussmaul WG, Krol J, Marzo KP et al: A randomized, controlled trial of the efficacy, safety and cost of a single-use myocardial bioptome. J Inv Cardiol 1993: 5, 148-152
6. Kussmaul WG, Marzo KP, Tomaszewsk J, DiSesa VJ: Rupture and entrapment of a balloon catheter in the LAD. Cath and Cardiovasc Diag. 1993; 28: 256
7. Marzo KP, Glanz S: Early restenosis following percutaneous transluminal balloon angioplasty for the treatment of the superior vena caval syndrome due to pacemaker-induced stenosis. Cath Cardiovasc Diag. 1995; 36(2): 128-31
8. Shea KW, Schwartz RK, Gambino AT, Marzo KP, Cunha BA. Bacteremia associated with percutaneous transluminal coronary angioplasty. Cath Cardiovasc Diag. 36:5-9, 1995
9. D’Agate DJ, Snyder CA, Marzo KP, Lazar J. Age-related decline in postextrasystolic potentiation in patients with aortic stenosis. Catheter Cardiovasc Interv. 2002 Jan. 55(1) 23-7
10. Miezczanska H, Lazar J, Marzo KP, Cunha BA. Cholesterol emboli mimicking acute bacterial endocarditis. Heart Lung 2002 Nov-Dec; 31 (6): 452-4
11. Durham JD, Caputo C. Dokko J, Zaharakis T, Pahlavan M, Keltz J, Dutka P, Marzo KP, Maesaka JK, Fishbane S. Related Articles, Links. A randomized controlled trial of N-acetylcysteine to prevent contrast nephropathy in cardiac angiography. Kidney Int. 2002 Dec; 62(6): 2002-7
12 Raio N, Cohen TJ, Daggubati R, Marzo K. Acute right coronary artery occlusion following radiofrequency ablation of atrial flutter. J Invasive Cardiol. 2005 Feb;17(2):92-3.
13. Fishbane S, Durham JH, Marzo K, Rudnick M. N-acetylcysteine in the prevention of radiocontrast-induced nephropathy. J Am soc Nephrol. 2004 Feb;15(2):251-60.
14 Davis A, Tramantano A., Marzo K. Perforation of the Ramus Intermedius and Fistula Formation with the Great Vein. J Invasive Cardiol, 2009;21:E57-59
15 Ghalchi M, Marzo KP Very Late Stent Thrombosis and Anti-neoplastic Therapy; Case Reports and Review Journal of Invasive Cardiology 2010 (in press)
D’Elia AA, Hafiz AM, Naidu SS, Chengot T, Marzo KP. Do Patients Undergoing Elective Percutaneous Coronary Intervention Understand Their Risk for Future Myocardial Infarction? J Am Coll Cardiol 2010;55(10):SA198.
Parikh PB, Gruberg L, Jeremias A, Chen JJ, Naidu SS, Shlofmitz RA, Brener SJ, Pappas T, Marzo KP, Brown DL. Impact of Health Insurance Status on Clinical Presentation, Management and Outcomes of Patients Undergoing Percutaneous Coronary Intervention. J Am Coll Cardiol 2010;55(10):SA
Parikh PB, Gruberg L, Jeremias A, Naidu SS, Shlofmitz RA, Brener SJ, Pappas T, Marzo KP, Brown DL. Impact of Dialysis-Dependent Renal Disease and Advanced Chronic Kidney Disease on In-hospital Outcomes in Patients Following Percutaneous Coronary Intervention. J Am Coll Cardiol 2010;55(10):SA140.
Gruberg L, Parikh PB, Jeremias A, Naidu SS, Shlofmitz RA, Brener SJ, Pappas T, Marzo KP, Brown DL. The Impact of Race on In-hospital Outcomes in Hemodialysis Patients Undergoing Percutaneous Coronary Intervention. J Am Coll Cardiol 2010;55(10):SA211.
Gruberg L, Parikh PB, Jeremias A, Naidu SS, Shlofmitz RA, Brener SJ, Pappas T, Marzo KP, Brown DL. Higher Mortality Rates after Percutaneous Coronary Intervention in Female Patients on Hemodialysis. J Am Coll Cardiol 2010;55(10):SA210.
Gruberg L, Jeremias A, Naidu SS, Brener S, Shlofmitz RA, Pappas T, Marzo K, Wilbert L, Brown DL. Anticoagulation Strategies During Primary Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction and Moderate to Severe Chronic Kidney Disease. Cardiovasc Revasc Medicine 2010;10(4):266.